BMS 318 Biomedical Informatics

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HIV-1 Pharmacogenomics in resource limited setting, Thailand: JITMM2010

Many HIV-infected patients have adverse reactions to anti-retroviral drugs, and others fail to take the drugs properly, which means resistance to the drugs may increase.


In Thailand, the government plans to provide free DNA testing to screen for adverse reactions, to help reduce the threat of resistance.

Many HIV-infected patients have adverse reactions to anti-retroviral drugs, and others fail to take the drugs properly, which means resistance to the drugs may increase.


In Thailand, the government plans to provide free DNA testing to screen for adverse reactions, to help reduce the threat of resistance.

Next Gen Viral load and Drug Resistant tests

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Visitors from Osaka University

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The Tentative International training Course on Management of ART for National and Local Program Manager

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SCPS 638 Exercise Genomics Human Polymorphism and analysis

Power point downloading, click here :http://cid-4676740196c7a6ac.office.live.com/browse.aspx/.Public

Real-Time PCR workshop Faculty of Dentistry SrinaKharWirot University

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RAPA 643 Genome Informatics

An overview: Genomics-Transcriptonomics-Proteomics
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RAPA609 update laboraotry diagnosis of viral infection

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Medical Data Standard Expo Aug21 2010

Integrating Genomics Information Standard
Wasun Chantratita, Ph.D.

The sequencing of the equivalent of an entire human genome for $1
,000 has been announced as a goal for the genetics community, and new technologies suggest that reaching this goal is a matter of a year from now, rather than if.

So what would we really do? The answer is simple; it is going to have a great benefit toward biomedical research and drug development. More importantly, a 'thousand-dollar genome' could become an important tool to realize personalized medicine: perfectly tailoring diagnostics and treatments to a patient's genetic make-up.

People would sequence themselves, their families. The Generic Genome Browser, the combination of database, interactive Web page, and plug-ins for manipulating and displaying annotations on genomes is becoming more standardized and will be in great demand.

For the end user, features of the browser include the ability to scroll and zoom through regions of a genome, to enter a region of the genome by searching for a landmark or performing a full text search of all features, and the ability to enable and disable tracks and change their relative order and appearance. The user can upload private annotations to view them in the context of the public ones, and publish those annotations to the community.

Another crucial step is the development of standards to enable the exchange of interrelated clinical and personalized genomic data between interested parties. In many cases the exchange of genomic data is done among these organizations (e.g., healthcare providers, genetic labs, research facilities, etc.) and acceptable standards are crucial for the usefulness of genomic data in healthcare practice.

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Education 2010

PAT313: Clinical Pathology

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Part1
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Part2
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Pharmacogenomics in resource limited setting, Thailand.

Why should be HIV pharmacogenomics?
Adverse drug reactions (ADRs) is a major factor contributing to the interruption of Antiretroviral drug (ARV) intake in HIV-1 infected patients. ARV non-adherence results in viral drug resistance, which derails ARV effectiveness and causes higher costs for complicated treatment regimens. The costlier second-line treatment regimens (2-9 times higher in price than first-line regimens) are unaffordable for individual or government agencies in developing countries.
This situation forms the development of a pharmacogenomics initiative in Thailand, with special focus on HIV.

The first target is to improve the prescription algorithm by personalizing the initial drug regimen; increasing the regimens efficacy; and simultaneously avoiding ADR.

The ultimate aim of this initiative is to minimize the cost of antiretroviral therapy for the public health system by incorporating research findings (“from bench to bedside”). Integrating our POC (point-of-care) HIV-1 pharmacogenetic screening tests and device into Thailand’s universal health-care system is a major challenge for the future and, if successfully implemented, they will eventually benefit both individuals and society.


Video Interviews:

Part one: From bench
Part two: To bedside (point-of-care device)

(Sorry, it is in Thai. English subtitle will soon be added)

ViRusRama

A Nonprofit, laboratory core facility offers various molecular diagnostics screening tests for pathogenic viruses ranging from real-time PCR to next generation sequencing.

Mission: To save life, improve quality of life, and reduce medical spending on antiviral drugs by using state-of-the-art molecular technology and bioinformatics.

Since  antiretroviral drugs have  various  efficacy and  side-effect profiles among individuals, therefore our unit have also involve in development of pharmacogenetic screening test based on genomic predictive markers obtained from Genome-wide association studies, exome, and whole genome re-sequencing including  bioinformatics interpretation tools

Contact: Wasun Chantratita, Ph.D.
Professor in Clinical Pathology 
Chief of Virology Unit
Ramathibodi hospital, Mahidol University
Bangkok 10400, Thailand

E-mail:wasun.cha@mahidol.ac.th
Telephone: 66-2-201-1470
Fax: 66-2-201-2115



How does ViRusRama look like?... Click!.


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Point of care DNA chip for pharmacogenetic screening test

NHK world news
HIV-1 Pharmacogenomics in resource limited setting, Thailand

Pyrosequencing for antiviral susceptibility testing

Voice of America (VOA): July24 2010

When H1N1, or swine flu, hit Thailand last year, the government at first restricted the use of antiviral drugs, worried that indiscriminate use would help the virus build drug resistance.

Dr. Wasun Chantratita studied hundreds of Thailand's 2009 influenza cases. He worries about resistance in H1N1 influenza, because it was deadlier than the 2008 seasonal flu.

Education 2010

RAPA612: Integrated Pathology: download PowerPoint:http://cid-4676740196c7a6ac.office.live.com/browse.aspx/.Public?uc=1